Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects

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Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects.

Several studies have suggested that genetic variations of the apolipoprotein (apo) AI-CIII-AIV cluster gene are associated with hyperlipidemia or atherosclerosis. These investigations were carried out mainly with Caucasian groups; there have been few associated studies involving non-Caucasian groups. This study was conducted to elucidate the association between five restriction fragment length ...

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Uncommon allele in apo AI-CIII-AIV gene cluster in a family with congenital generalized lipodystrophy.

Congenital generalized lipodystrophy is a rare inherited disease. One of its features is a disturbance in lipid metabolism characterized by hypercholesterolemia and hypertriglyceridemia. A brother and a sister with congenital generalized lipodystrophy, an 8-year old male and a 12-year old female were studied. The mother and a 6-year old brother were healthy. The genetic analysis of Sstl RFLP of...

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Genetic variation of the Apo Al-CIII-AIV gene cluster in hypertriglyceridemic patients with chronic renal failure undergoing hemodialysis.

Many patients with chronic renal failure (CRF) requiring hemodialysis present with hypertriglyceridemia (HTG). But the exact cause of HTG in CRF is still unknown. Genetic variation of the apo AI-CIII-AIV gene cluster was reported to be associated with primary HTG, atherosclerosis and coronary artery disease. This study was designed to evaluate the association between the restriction fragment le...

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Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.

Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis, and T.W.A. de Bruin. J. Lipid Res., 1996, 36:136-147) we have studied three restriction enzyme polymorphisms: XmnI, and MspI sites 5' of the apo AI gene and SstI site in the 3' untranslated region o...

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بررسی پلی‌مورفیسم ژنهای آپولیپوپروتئین‌های AI و CIII در بیماران مبتلا به گرفتگی عروق کرونر

Several polymorphisms within the apo AI-CIII-AIV gene cluster have been detected there is ample evidence about variations at the adjucent apo AI and apo CIII gene loci influence the risk for hypertriglyceridemia and coronary artery disease(CAD). This study was conducted to elucidate the association between two restriction fragment length polymorphisms(RFLPs) of the adjacent apo AI and...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 1997

ISSN: 0009-9147,1530-8561

DOI: 10.1093/clinchem/43.1.13